Landmark trial
Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases: A Randomized Clinical Trial
Brown PD, Jaeckle K, Ballman KV, et al. · Alliance / NCCTG
DoseLab summary
Phase 3 trial (NCCTG N0574) in patients with 1–3 brain metastases: adding whole-brain radiotherapy to radiosurgery caused more cognitive decline at 3 months without improving survival. Citation checked against Crossref.
Why this is useful
One of the trials that moved limited brain metastases from whole-brain treatment to radiosurgery alone.
Reference details
- Title
- Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases: A Randomized Clinical Trial
- Authors / organization
- Brown PD, Jaeckle K, Ballman KV, et al. · Alliance / NCCTG
- Publication / protocol
- JAMA. 2016;316(4):401–409
- Version
- Pending verification
- Year
- 2016
- DOI
- 10.1001/jama.2016.9839
- Disease sites
- CNS / Brain
- Topics
- SRS, Whole brain, Brain metastases, Landmark trial
- Fractionation context
- Pending verification
- Last reviewed by DoseLab
- Pending verification