The template NRG Oncology gives investigators for writing the radiation therapy section of an anal cancer trial. Its example text and values are based on RTOG 0529 and the ECOG-ACRIN DECREASE trial (EA2182), and are meant to be edited for each protocol. It covers immobilization (a supine "frog-leg" position is recommended), CT or PET/CT simulation, rigid registration of MRI and PET to the planning CT, standard structure names, dose compliance tables and planning priorities.
Pelvis contouring
How to find each organ on CT, in DoseLab's own words, with the published source behind every boundary. Always check the protocol you are planning to.
Organ contouring guides
Anus / Anal Canal
Function in the body
The anus is the last part of the bowel; its sphincter muscles control the passing of stool.
How to contour
- The NRG anal cancer template describes the anal canal as running from the anal verge to the anorectal junction, with the internal and external sphincter muscles around it.
- Gay 2012's AnoRectum combines the anus and rectum, starting at the anal verge marked with a radiopaque marker at simulation.
- In the NRG vulva template the rectum starts 2 cm above the anal verge, so the anus covers the segment below it.
Contour the anus separately from the rectum when your protocol limits them separately, and check that the two contours meet without gaps or overlap.
Bladder
Function in the body
The bladder stores urine until it is passed.
How to contour
- Gay 2012: from the base to the dome.
- The NRG anal cancer template: contour the outer bladder wall and fill it in as a solid structure.
- Timmerman 2022 (Tables 8–11, written for its SBRT dose tables): the bladder wall and all urine, ending at the base of the prostate. Timmerman also defines a suprapubic bladder wall structure — the front, lower wall resting on the pubic bone, from the prostate up 2–3 cm.
Bladder filling changes the volume a lot, so follow your protocol's filling instructions.
External Genitalia & Perineum
Function in the body
The external genitalia are the outer sex organs.
How to contour
The NRG anal cancer template requires a "Genitals" structure — male or female external genitalia — and notes that consistent repositioning of male genitalia at simulation and treatment matters. It gives no further boundaries. Detailed boundaries from an open published source: verified source required; contour as your protocol describes.
Femoral Heads
Function in the body
The femoral head is the ball of the hip joint, carrying the body's weight from the pelvis to the leg.
How to contour
Sources draw quite different structures:
- Gay 2012 (proximal femur): from the top of the ball of the femur down to the lowest level of the ischial tuberosities, including the trochanters. A bone threshold auto-contour helps, but edit it afterwards.
- The NRG anal cancer template (femoral head): the femoral head excluding the femoral neck, with the bottom border at the lesser trochanter.
- Timmerman 2022 (Tables 8–11, written for its SBRT dose tables): contour the right and left separately.
Because the volumes differ, a limit only makes sense on the structure it was written for.
Pelvic Bone Marrow
Function in the body
Bone marrow makes the body's blood cells; in adults, much of the active marrow lies in the pelvic bones.
How to contour
The NRG anal cancer template contours BoneMarrow from the outer bone contours of the sacrum, iliac crests, acetabula and proximal femurs as one solid, continuous structure, stopping at the bottom at the level of the ischial tuberosities.
Definitions vary between protocols, and a limit applies only to the structure it was written for, so match your contour to your protocol.
Penile Bulb
Function in the body
The penile bulb is the base of the corpus spongiosum, the erectile tissue around the urethra at the root of the penis.
How to contour
Gay 2012: the part of the bulbous spongiosum immediately below the urogenital diaphragm; do not extend it forward into the shaft. It is best seen on MRI (bright on T2) or on CT with contrast in the urethra; on CT it sits behind the urethra and is round.
Timmerman 2022 (Tables 8–11, written for its SBRT dose tables): start at the bottom of the pelvic diaphragm (urethral sphincter) and extend down and forward up to 3 cm.
Rectum
Function in the body
The rectum stores stool before it leaves the body.
How to contour
Gay 2012 gives two versions:
- Rectum (GU): from the lowest level of the ischial tuberosities up to where the rectum loses its round shape on axial images and joins the sigmoid in front.
- AnoRectum (GYN): the same top, but starting at the anal verge marked at simulation, so it includes the anus.
Timmerman 2022 (Tables 8–11, written for its SBRT dose tables): one structure including the rectal wall and all contents; its Table 9 instruction reads "start contouring 10 cm superior to PTV then inferior to anal sphincter." Make sure your rectum and anus contours match the definitions behind your limits.
Urethra
Function in the body
The urethra carries urine from the bladder out of the body; its first part runs through the prostate.
How to contour
In Richardson 2021 the prostatic urethra was contoured inside the prostate CTV from the bladder neck to the prostate apex, on the sagittal view with a 2 mm brush. Large TURP defects inside the CTV were included. A further 3 mm expansion made a cylindrical urethra PRV.
The study found a thin (0.9 mm), 3D T2-weighted MRI cut variation between observers markedly compared with planning CT or a standard 3 mm T2 scan. The urethra can still need some estimation, so use the method your protocol describes.
Also used here, listed once under another region: Spinal Cord (Head & Neck).
Sources
The published guidelines and atlases cited in the guides above. Open the original for the full boundary tables and images.
The NRG Oncology template for the radiation section of a vulvar cancer trial. It covers supine frog-leg or straight-leg setup, wires on gross disease and scars, bolus or virtual bolus, diagnostic MRI and PET/CT fusion (ideally in the treatment position), structure names including the anus and bolus, prescriptions for locally advanced and post-operative treatment with an SIB or a sequential boost, and organ goals evaluated on the composite plan. Its values are examples meant to be edited for each trial.
An editorial history of the UT Southwestern SABR constraint tables — often called the “Timmerman tables” — covering how they were developed and revised, and their relationship to AAPM TG-101 and NRG/RTOG protocols. Tables 2–11 separate serial tissues (listed with a volume, a volume max and a max point dose) from parallel tissues (listed with a critical volume and a critical-volume dose max). In Tables 2–7 a footnote defines “point” as ≤0.035 cm³; Tables 8–11 add a contouring-instructions column for each structure.
RTOG consensus panel atlas of male and female pelvic normal tissues. Citation as given in the eviQ reference list; not yet checked against the journal.
Practical guidance on visualizing the urethra for prostate planning. Citation as given in the eviQ reference list; not yet checked against the journal.